News From Dr. Vidt
Lens Luxation Study at the University of Missouri
 Lens Luxation Study at University of Missouri
Primary lens luxation is an eye problem which is hereditary on the Chinese Shar-Pei. The lens is held in place in the eye by fibers called zonules. If these fibers are weak, not located properly around the circumference of the lens capsule, or break, the lens can fall out of its normal position or “luxate”. The lens typically moves forward against the iris blocking the pupil and interfering with movement of aqueous fluid into the drainage angle which is located around the base of the iris. This can result in an increase in intraocular pressure known as secondary glaucoma which can result in loss of vision.
When the lens luxates immediate veterinary attention is required to remove the displaced lens and prevent secondary glaucoma and loss of vision.
The University of Missouri College of Veterinary Medicine has developed a DNA test for primary lens luxation in the Chinese Shar-Pei. It has been found in the same gene that causes primary lens luxation in other breeds but is caused by a different mutation at this location. Dr. Gary Johnson is requesting blood samples from Shar-Pei to test for the mutation. He suggested that any Shar-Pei with glaucoma should be evaluated for primary lens luxation. The accompanying PDF download has all the necessary information for Shar-Pei owners to participate in the study. Thanks, in advance, for your help in this study.
Jeff Vidt, DVM
Chairman of the Health Committee, CSPCA (4/2010)
2009 - The AKC Canine Health Foundation National Parent Club Canine Health Conference (NPCCHC)
On October 23-25, 2009 I attended the AKC Canine Health Foundation 2009 National Parent Club Health Conference held in St. Louis, Missouri. This was the seventh conference which is held biannually and was sponsored by Nestlé Purina PetCare Company. The purpose of the conference is several-fold. It brings together many of the top researchers in the canine health field to bring the attendees up to speed on their AKC-CHF grant projects. It also allows the various parent club health representatives to catch their vision of the future – future diagnostic tests, future areas of research, and future therapies for canine health issues. On Friday there were several Round Table Discussions focusing on areas such as canine health surveys, the CHIC program, use of genetic tests, fundraising techniques and ideas, etc. We were privileged to have a number of veterinary students from across the country in attendance who received corporate and private scholarships to be there. They attended a special round table session held by the OFA (Orthopedic Foundation for Animals).
On Saturday the key note speaker set the theme of this year’s conference as “One Health, One Medicine”. This reminded us that the health of humans and animals are intricately linked to each other.
This was further reinforced by the next speaker Dr. Matthew Breen who spoke on “Canine Cancer and Comparative Genomics” and reminded us that there is an 80-90% homology between the human and canine genome. Practically speaking this means research in human diseases will benefit dogs and conversely, research in canine disease will directly benefit human medicine. He also showed how the work on the Canine Genome Project which was completed in 2005 has exponentially increased the advancement of research in genetic disease and the advancement in technology to facilitate this research. In the afternoon there were presentations on new diagnostic and therapeutic investigations in canine neurologic disease and advances in canine cardiac research. The conference finished up Sunday morning with a presentation on the genetic basis of urate bladder stones in Dalmatians and how this research has helped in two other breeds prone to urate stones – the Bulldog and the Black Russian Terrier. In between sessions there were some good meals, entertainment and fellowship with other breed health chairs.
I came away with the following insights:
- The Chinese Shar-Pei is not alone in having genetically-based disease problems.
- While the CSPCA Charitable Trust often funds canine health research in areas that do not
specifically focus on our breed this research does help other breeds and also people. Many of the cancer research projects we helped sponsor have helped the Shar-Pei as demonstrated by the release of Palladia® for canine mast cell cancer.
- We are a part of the canine community and we need to help and support each other.
- We are fortunate to have many dedicated scientists, laboratory workers, doctors, universities, research centers, corporations, dog breed clubs, dog owners and many other benefactors to help us in our goal of having healthier dogs.
- Our money is not wasted. The AKC Canine Health Foundation is very selective in its grant funding and solicits the very best researchers. The CHF requires periodic feedback on the projects it funds to determine if the grant money is being used in the best possible way.
Jeff Vidt, DVM
Here is a copy of a letter by the Heart of America Chinese Shar-Pei Club and the Centennial Chinese Shar-Pei Club requesting financial support for the CSPCA Health Through Education Committee and the Chinese Shar-Pei Charitable Trust. I received permission to put it on my web site in order to bring this need before Shar-Pei owners who are not members of the Chinese Shar-Pei Club of America. I know you are concerned about the health needs of our breed as well and will respond appropriately. I thank you in advance for your support:
 Read Letter |
